neuroots.co

Regulatory Developments in Gene Therapy for Huntington’s Disease: Perspectives from uniQure’s Engagement with the U.S. Food and Drug Administration

uniQure N.V., a prominent entity in the gene therapy domain focused on developing innovative interventions for individuals with profound medical conditions, recently disclosed outcomes from a pre-Biologics License Application (BLA)…

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Clinical Trials

Empirically Validated Insights from Peer-Reviewed Research on Repeated LSD Microdosing (as of November 28, 2025)

Recent advancements in psychedelic research have examined the therapeutic potential of repeated low-dose LSD administration, commonly termed microdosing. A pivotal investigation, representing the most extensive placebo-controlled study in major depressive…

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Glial Heterogeneity in Ischemic Stroke: Insights from Single-Nucleus RNA Sequencing

In recognition of outstanding contributions to neuroscience, the “Researcher of the Month” jury at the Medical University of Vienna has awarded the November 2025 distinction to Dr. Daniel Bormann for…

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NF-κB Orchestrates a Dual Transcriptional Program in Hypoxia with Predominant Control over Gene Repression

Hypoxia triggers conserved adaptive cellular programmes that restore oxygen homeostasis or mitigate its deficit. Central to the oxygen-sensing machinery are the hypoxia-inducible factors (HIFs), whose stability and activity are governed…

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Toxicology

Exposure to Environmental Pesticides and Industrial Chemicals Disrupts the Human Gut Microbiota

Emerging evidence indicates that chronic low-level exposure to anthropogenic chemicals, including agricultural pesticides and industrial pollutants, may exert unintended antimicrobial effects on the human gut microbiome. A comprehensive in vitro…

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BNM MND Science & Research

The Neuroprotective Potential of Panax ginseng in Neurodegenerative Diseases: Molecular Mechanisms, Therapeutic Evidence, and Translational Perspectives

Neurodegenerative disorders, encompassing Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), and Huntington’s disease (HD), constitute a major and escalating public health burden in ageing…

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BNM MND Neuroscience

Bypassing Pluripotency: Scalable Direct Reprogramming of Dermal Fibroblasts into Functional Motor Neurons for Regenerative Therapy

Researchers at the Massachusetts Institute of Technology have developed a highly efficient protocol for the direct conversion of dermal fibroblasts into mature motor neurons, circumventing the intermediate pluripotent stem cell…

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Nanostructured Particles Facilitate Mitochondrial Augmentation and Intercellular Transfer to Restore Cellular Energetics in Senescent and Pathological States

In a seminal investigation conducted by researchers in the Department of Biomedical Engineering at Texas A&M University, a novel biomaterial-based strategy has been elucidated to counteract the progressive diminution of…

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Chimeric Antigen Receptor T-Cell Interventions Achieve Sustained Remission in Refractory Autoimmune Conditions

Chimeric antigen receptor (CAR) T-cell therapies, initially developed for oncological applications, have demonstrated substantial therapeutic potential in modulating aberrant immune responses underlying autoimmune pathologies, including ulcerative colitis, rheumatoid arthritis, and…

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Lifestyle & Health

Fish, Blood Types, and Mental Balance: Insights from Scientific Studies

Fish consumption, particularly rich in omega-3 fatty acids like EPA and DHA, has been extensively studied for its role in supporting brain health and mental well-being. Systematic reviews and…