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Toxicology

Exposure to Environmental Pesticides and Industrial Chemicals Disrupts the Human Gut Microbiota

Emerging evidence indicates that chronic low-level exposure to anthropogenic chemicals, including agricultural pesticides and industrial pollutants, may exert unintended antimicrobial effects on the human gut microbiome. A comprehensive in vitro screening study recently published in Nature Microbiology demonstrates that a substantial proportion of commonly encountered environmental chemicals can inhibit the growth of commensal gut bacterial…

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Extracellular Vesicles as Mediators of Systemic Toxic Injury Propagation: A Neuroscience and Molecular Biology Perspective

Extracellular vesicles (EVs), particularly exosomes and microvesicles, are a highly conserved intercellular communication system. Under severe toxic stress, EVs can transfer not only physiological signals but also full cellular injury programs to distant tissues — without the toxin itself ever reaching the target cells. Here we review the robust experimental evidence available as of November…

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