neuroots.co

Assessment of Cannabidiolic Acid’s Neuroprotective Potential in a TDP-43 Transgenic Mouse Model of Amyotrophic Lateral Sclerosis

Cannabinoids originating from plants, such as Δ9-tetrahydrocannabinol (Δ9-THC), cannabinol, and formulations resembling Sativex, have demonstrated neuroprotective properties in various preclinical models of amyotrophic lateral sclerosis (ALS). Nevertheless, the therapeutic potential…

03

Science & Research

Peptides, NAD⁺, and MOTS-c: Evidence-Based Insights into Their Roles in Longevity as of 2025

In the domain of longevity research, peptides have garnered significant attention, yet only a subset demonstrates robust mechanistic support derived from empirical investigations. This review synthesizes validated findings from preclinical…

02

Epigenetics

A Unified Prime Editing Strategy for Mitigating Diverse Genetic Disorders

Advancements in genome editing have introduced a novel approach capable of addressing a substantial proportion of rare genetic conditions, potentially enhancing the scalability of therapeutic interventions for affected individuals. This…

02

BNM Clinical Trials Epigenetics MND

Revolutionizing ALS Clinical Trials: A New Era Ahead

ALS research is transforming rapidly! From isolated studies to global networks, trials now boost patient access, speed up data collection, and cut timelines. Key shifts: multicenter collaborations reaching more…

30

Lifestyle & Health Science & Research

Targeting Aging Pathways with GLP-1 Analogs: From Metabolic Disorders to Healthspan Extension

During the August convening of the Aging Research and Drug Discovery conference in Copenhagen, representatives from Novo Nordisk and Eli Lilly captivated attendees by positing that glucagon-like peptide-1 receptor agonists…

30

MND

Assessment of Residual Plasmid DNA and SV40 Promoter-Enhancer Elements in modRNA-Based COVID-19 Vaccines from Pfizer-BioNTech and Moderna Sourced in Ontario, Canada

David J. Speicher and colleagues. Autoimmunity. 2025 Dec;58(1):2551517. doi: 10.1080/08916934.2025.2551517. Epub 2025 Sep 6. Abstract In the development of certain COVID-19 vaccines, variations occurred between the manufacturing processes for drug…

30

AI

Advancements in Artificial Intelligence for Variant Pathogenicity Prediction in Genetic Disorders

The human genome harbors numerous subtle sequence variations, termed variants, which influence protein synthesis within cellular processes. Among these, only a minority exert deleterious effects on protein function, thereby contributing…

30

Science & Research

Advancements in Antimalarial Therapy: Phase III Outcomes for a Novel Ganaplacide-Lumefantrine Combination

Recent Phase III trial data from Novartis have demonstrated the efficacy of GanLum, an innovative antimalarial regimen comprising ganaplacide and lumefantrine, representing the first novel therapeutic approach for malaria in…

29

News & Events

Artificial Intelligence in Enhancing the Predictability of CRISPR-Based Genome Editing

Advancements in artificial intelligence (AI) are increasingly intersecting with genome editing technologies, potentially mitigating the inherent uncertainties associated with CRISPR systems. This integration aims to streamline experimental workflows and improve…

29

Clinical Trials News & Events

A Novel Off-the-Shelf mRNA Vaccine Enters Human Trials for Cancer Treatment

A novel mRNA therapeutic vaccine targeting cancer has progressed to clinical evaluation in humans, offering the potential to broaden therapeutic avenues across diverse tumor types through activation of the host’s…