Assessment of Cannabidiolic Acid’s Neuroprotective Potential in a TDP-43 Transgenic Mouse Model of Amyotrophic Lateral Sclerosis

Cannabinoids originating from plants, such as Δ9-tetrahydrocannabinol (Δ9-THC), cannabinol, and formulations resembling Sativex, have demonstrated neuroprotective properties in various preclinical models of amyotrophic lateral sclerosis (ALS). Nevertheless, the therapeutic potential of lesser-known phytocannabinoids, including cannabidiolic acid (CBDA), has not been extensively investigated. The present investigation examined the neuroprotective capabilities of CBDA, alongside cannabidivarin, cannabidiol (CBD),…

Byneuroots.coDecember 9, 20250Comments

BNM Clinical Trials Epigenetics MND

Revolutionizing ALS Clinical Trials: A New Era Ahead

ALS research is transforming rapidly! From isolated studies to global networks, trials now boost patient access, speed up data collection, and cut timelines. Key shifts: multicenter collaborations reaching more people and adaptive designs for efficiency. Biomarkers like neurofilament light chain are game-changers—detecting changes early, as seen in tofersen’s approval. They’re integrated into trials…

Byneuroots.coDecember 2, 20250Comments

MND

Assessment of Residual Plasmid DNA and SV40 Promoter-Enhancer Elements in modRNA-Based COVID-19 Vaccines from Pfizer-BioNTech and Moderna Sourced in Ontario, Canada

David J. Speicher and colleagues. Autoimmunity. 2025 Dec;58(1):2551517. doi: 10.1080/08916934.2025.2551517. Epub 2025 Sep 6. Abstract In the development of certain COVID-19 vaccines, variations occurred between the manufacturing processes for drug substances intended for market release and those employed during clinical evaluations. The production of nucleoside-modified messenger RNA (modRNA) for these commercial vaccines involves in vitro…

Byneuroots.coNovember 30, 20250Comments

BNM MND Science & Research

The Neuroprotective Potential of Panax ginseng in Neurodegenerative Diseases: Molecular Mechanisms, Therapeutic Evidence, and Translational Perspectives

Neurodegenerative disorders, encompassing Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), and Huntington’s disease (HD), constitute a major and escalating public health burden in ageing societies worldwide. These conditions are defined by the progressive degeneration and loss of specific neuronal populations, resulting in profound cognitive decline, motor disability, and behavioural…

Byneuroots.coNovember 27, 20250Comments

BNM MND Neuroscience

Bypassing Pluripotency: Scalable Direct Reprogramming of Dermal Fibroblasts into Functional Motor Neurons for Regenerative Therapy

Researchers at the Massachusetts Institute of Technology have developed a highly efficient protocol for the direct conversion of dermal fibroblasts into mature motor neurons, circumventing the intermediate pluripotent stem cell stage traditionally required for neuronal differentiation. This lineage reprogramming approach yields more than ten motor neurons per starting fibroblast in murine cells and achieves successful…

Byneuroots.coNovember 27, 20250Comments

MND Neuroscience Science & Research Toxicology

Extracellular Vesicles as Mediators of Systemic Toxic Injury Propagation: A Neuroscience and Molecular Biology Perspective

Extracellular vesicles (EVs), particularly exosomes and microvesicles, are a highly conserved intercellular communication system. Under severe toxic stress, EVs can transfer not only physiological signals but also full cellular injury programs to distant tissues — without the toxin itself ever reaching the target cells. Here we review the robust experimental evidence available as of November…

Byneuroots.coNovember 26, 20250Comments

MND

From Diabetes Drug to Neural Rejuvenator: Exenatide Restores Youthful Gene Expression and Cognition in Aging

In the quest to combat neurodegenerative processes and cognitive decline, the neuroscience community has long sought interventions that target the brain’s intricate aging biology. Glucagon-like peptide-1 receptor agonists (GLP-1RAs), such as exenatide—originally developed for type 2 diabetes management—have shown promise beyond metabolic control. A groundbreaking study published in Cell Metabolism reveals that low-dose exenatide…

Byneuroots.coNovember 25, 20250Comments

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Exclusive: Dr. Ariel Ionescu on the microRNA-126 Breakthrough That’s Giving New Hope to ALS

Ariel Ionescu, the scientist who co-founded Rinnerva Therapeutics and has spent years developing a truly innovative therapy for amyotrophic lateral sclerosis (ALS), sat down with Nicolae Tomescu. In this exclusive interview for SLA România – first published on NEUROOTS.co – Dr. Ionescu gives the straight answers to the questions that matter most to the ALS…

Byneuroots.coNovember 24, 20251Comment

MND

Repairing the Stomach: Rebuilding the Foundation of Health

Inspired by the Prophetic Teaching: “The stomach is the house of disease, and diet is the head of treatment.” Introduction Modern medical research continues to confirm a timeless truth spoken by the Prophet Muhammad ﷺ: “The stomach is the house of disease, and diet is the head of treatment.” The stomach and broader gastrointestinal tract…

Byneuroots.coNovember 20, 20250Comments

MND

Your Supermarket Yogurt Is Lying to You – Here’s What Real Fermented Dairy Actually Does to Your Body

Your yogurt (and other fermented dairy) is far more than just “probiotic” It is a dynamic source of over 700 bioactive compounds (peptides, exopolysaccharides, organic acids, sphingolipids, vitamins, etc.), whose profile varies significantly depending on the raw milk source, fermentation temperature, starter culture composition, and production method (Valle et al., 2023 – untargeted metabolomics of…

Byneuroots.coNovember 20, 20250Comments