Assessment of Cannabidiolic Acid’s Neuroprotective Potential in a TDP-43 Transgenic Mouse Model of Amyotrophic Lateral Sclerosis

Cannabinoids originating from plants, such as Δ9-tetrahydrocannabinol (Δ9-THC), cannabinol, and formulations resembling Sativex, have demonstrated neuroprotective properties in various preclinical models of amyotrophic lateral sclerosis (ALS). Nevertheless, the therapeutic potential of lesser-known phytocannabinoids, including cannabidiolic acid (CBDA), has not been extensively investigated. The present investigation examined the neuroprotective capabilities of CBDA, alongside cannabidivarin, cannabidiol (CBD),…

Byneuroots.coDecember 9, 20250Comments

BNM Clinical Trials Epigenetics MND

Revolutionizing ALS Clinical Trials: A New Era Ahead

ALS research is transforming rapidly! From isolated studies to global networks, trials now boost patient access, speed up data collection, and cut timelines. Key shifts: multicenter collaborations reaching more people and adaptive designs for efficiency. Biomarkers like neurofilament light chain are game-changers—detecting changes early, as seen in tofersen’s approval. They’re integrated into trials…

Byneuroots.coDecember 2, 20250Comments

BNM MND Science & Research

The Neuroprotective Potential of Panax ginseng in Neurodegenerative Diseases: Molecular Mechanisms, Therapeutic Evidence, and Translational Perspectives

Neurodegenerative disorders, encompassing Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), and Huntington’s disease (HD), constitute a major and escalating public health burden in ageing societies worldwide. These conditions are defined by the progressive degeneration and loss of specific neuronal populations, resulting in profound cognitive decline, motor disability, and behavioural…

Byneuroots.coNovember 27, 20250Comments

BNM MND Neuroscience

Bypassing Pluripotency: Scalable Direct Reprogramming of Dermal Fibroblasts into Functional Motor Neurons for Regenerative Therapy

Researchers at the Massachusetts Institute of Technology have developed a highly efficient protocol for the direct conversion of dermal fibroblasts into mature motor neurons, circumventing the intermediate pluripotent stem cell stage traditionally required for neuronal differentiation. This lineage reprogramming approach yields more than ten motor neurons per starting fibroblast in murine cells and achieves successful…

Byneuroots.coNovember 27, 20250Comments

A Personal View BNM

Exclusiv: Dr. Ariel Ionescu despre descoperirea revoluționară cu microRNA-126 care aduce o nouă speranță în ALS/SLA

Ariel Ionescu, omul de știință care a pus bazele Rinnerva Therapeutics și lucrează de ani buni la un tratament cu adevărat inovator pentru scleroza laterală amiotrofică, a stat de vorbă cu Nicolae Tomescu, în premieră pentru SLA România – și vine exact cu răspunsurile la întrebările care contează cel mai mult pentru comunitate. “Munca abia…

Byneuroots.coNovember 24, 20250Comments

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Exclusive: Dr. Ariel Ionescu on the microRNA-126 Breakthrough That’s Giving New Hope to ALS

Ariel Ionescu, the scientist who co-founded Rinnerva Therapeutics and has spent years developing a truly innovative therapy for amyotrophic lateral sclerosis (ALS), sat down with Nicolae Tomescu. In this exclusive interview for SLA România – first published on NEUROOTS.co – Dr. Ionescu gives the straight answers to the questions that matter most to the ALS…

Byneuroots.coNovember 24, 20251Comment