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The Endocannabinoid System (ECS)

BNM Canna Herbal Therapeutics MND Neuroscience Science & Research The Endocannabinoid System (ECS)

Assessment of Cannabidiolic Acid’s Neuroprotective Potential in a TDP-43 Transgenic Mouse Model of Amyotrophic Lateral Sclerosis

Cannabinoids originating from plants, such as Δ9-tetrahydrocannabinol (Δ9-THC), cannabinol, and formulations resembling Sativex, have demonstrated neuroprotective properties in various preclinical models of amyotrophic lateral sclerosis (ALS). Nevertheless, the therapeutic potential of lesser-known phytocannabinoids, including cannabidiolic acid (CBDA), has not been extensively investigated. The present investigation examined the neuroprotective capabilities of CBDA, alongside cannabidivarin, cannabidiol (CBD),…
December 9, 20250Comments

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Advocacy Canna Herbal Therapeutics Lifestyle & Health People & Culture Policy & Public Interest Science & Research The Endocannabinoid System (ECS)

After 100 Years of Lies and Prohibition, Cannabis Just Broke Into Mainstream Medicine Like Nothing Else Ever Has

A fascinating and often overlooked fact is that cannabis is one of the very few plants to have been officially integrated into modern allopathic (conventional) medicine not merely as a dietary supplement or traditional herbal remedy, but as a fully regulated prescription medicine available in pharmacies. This integration is supported by rigorous scientific evidence from…
November 21, 20250Comments

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Clinical Trials Herbal Therapeutics The Endocannabinoid System (ECS)

Canna Treatment Associated With Prolonged Survival in Patients With Aggressive Form of Cancer

Mahasarakham, Thailand: Patients diagnosed with cholangiocarcinoma (biliary tract cancer) who integrate cannabis into their palliative medical treatment experience prolonged survival compared to those who do not, according to the findings of a retrospective cohort study published in the scientific journal F1000 Research. Thai investigators compared survival trends among 491 patients diagnosed with advanced CCA (cholangiocarcinoma). Of these, 404 patients received palliative…
November 20, 20250Comments

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Clinical Trials Herbal Therapeutics The Endocannabinoid System (ECS)

Cannabinoid Therapy as a Modulator of Glutamatergic–GABAergic Imbalance After Traumatic Brain Injury: A Scientifically Validated Review

Traumatic brain injury (TBI) induces a profound disruption of the excitatory–inhibitory balance through excessive glutamate release (excitotoxicity) and impaired GABAergic inhibition. Preclinical evidence, supported by multiple peer-reviewed studies, demonstrates that cannabidiol (CBD) and other cannabinoids can attenuate cortical glutamate surge, preserve or enhance GABAergic signaling, reduce neuroinflammation, and limit secondary neuronal damage. This review synthesizes…
November 20, 20250Comments

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Clinical Trials Herbal Therapeutics The Endocannabinoid System (ECS)

Cannabinoids CBD and CBDV – A Breakthrough in the Fight Against Fungal Infections

Recent research confirms what advocates of natural medicine have claimed for years: natural cannabinoids, particularly CBD (cannabidiol) and CBDV (cannabidivarin), in their complete, unaltered plant form, possess remarkable antifungal properties. A study published on June 5, 2025, in the prestigious journal PLOS Neglected Tropical Diseases convincingly demonstrated that these natural compounds can combat a wide…
November 20, 20250Comments

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Clinical Trials MND The Endocannabinoid System (ECS)

How CBD Enhances Exercise Endurance and the Role of Gut Bacteria

A study published in 2024 investigated how cannabidiol (CBD), a non-psychoactive compound derived from the cannabis plant, affects physical endurance in mice. Researchers observed that CBD administration made skeletal muscles more resistant to fatigue and improved mitochondrial function, the primary energy-producing structures within cells. These beneficial effects were found to depend heavily on CBD-induced changes…
November 20, 20250Comments

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Herbal Therapeutics MND Neuroscience The Endocannabinoid System (ECS)

The Endocannabinoid System & Autoimmune Disease: A Critical but Overlooked Connection

Why Medicine Can No Longer Afford to Ignore It For decades, the endocannabinoid system (ECS) — the body’s largest neuromodulatory network — has been treated as a footnote in medical education. While students spend hundreds of hours mastering the renin-angiotensin system or the hypothalamic-pituitary-adrenal axis, most graduate knowing little or nothing about the physiological system…
November 20, 20250Comments

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