Assessment of Cannabidiolic Acid’s Neuroprotective Potential in a TDP-43 Transgenic Mouse Model of Amyotrophic Lateral Sclerosis

9 months ago
neuroots.co

Cannabinoids originating from plants, such as Ξ”9-tetrahydrocannabinol (Ξ”9-THC), cannabinol, and formulations resembling Sativex, have demonstrated neuroprotective properties in various preclinical…

Peptides, NAD⁺, and MOTS-c: Evidence-Based Insights into Their Roles in Longevity as of 2025

9 months ago

In the domain of longevity research, peptides have garnered significant attention, yet only a subset demonstrates robust mechanistic support derived…

A Unified Prime Editing Strategy for Mitigating Diverse Genetic Disorders

9 months ago

Advancements in genome editing have introduced a novel approach capable of addressing a substantial proportion of rare genetic conditions, potentially…

Revolutionizing ALS Clinical Trials: A New Era Ahead

9 months ago

ALS research is transforming rapidly! From isolated studies to global networks, trials now boost patient access, speed up data collection,…

Targeting Aging Pathways with GLP-1 Analogs: From Metabolic Disorders to Healthspan Extension

10 months ago

During the August convening of the Aging Research and Drug Discovery conference in Copenhagen, representatives from Novo Nordisk and Eli…

Assessment of Residual Plasmid DNA and SV40 Promoter-Enhancer Elements in modRNA-Based COVID-19 Vaccines from Pfizer-BioNTech and Moderna Sourced in Ontario, Canada

10 months ago

David J. Speicher and colleagues. Autoimmunity. 2025 Dec;58(1):2551517. doi: 10.1080/08916934.2025.2551517. Epub 2025 Sep 6. Abstract In the development of certain…

Advancements in Artificial Intelligence for Variant Pathogenicity Prediction in Genetic Disorders

10 months ago

The human genome harbors numerous subtle sequence variations, termed variants, which influence protein synthesis within cellular processes. Among these, only…

Advancements in Antimalarial Therapy: Phase III Outcomes for a Novel Ganaplacide-Lumefantrine Combination

10 months ago

Recent Phase III trial data from Novartis have demonstrated the efficacy of GanLum, an innovative antimalarial regimen comprising ganaplacide and…

Artificial Intelligence in Enhancing the Predictability of CRISPR-Based Genome Editing

10 months ago

Advancements in artificial intelligence (AI) are increasingly intersecting with genome editing technologies, potentially mitigating the inherent uncertainties associated with CRISPR…

A Novel Off-the-Shelf mRNA Vaccine Enters Human Trials for Cancer Treatment

10 months ago

A novel mRNA therapeutic vaccine targeting cancer has progressed to clinical evaluation in humans, offering the potential to broaden therapeutic…