Assessment of Cannabidiolic Acid’s Neuroprotective Potential in a TDP-43 Transgenic Mouse Model of Amyotrophic Lateral Sclerosis

2 months ago
neuroots.co

Cannabinoids originating from plants, such as Ξ”9-tetrahydrocannabinol (Ξ”9-THC), cannabinol, and formulations resembling Sativex, have demonstrated neuroprotective properties in various preclinical…

Peptides, NAD⁺, and MOTS-c: Evidence-Based Insights into Their Roles in Longevity as of 2025

2 months ago

In the domain of longevity research, peptides have garnered significant attention, yet only a subset demonstrates robust mechanistic support derived…

A Unified Prime Editing Strategy for Mitigating Diverse Genetic Disorders

2 months ago

Advancements in genome editing have introduced a novel approach capable of addressing a substantial proportion of rare genetic conditions, potentially…

Revolutionizing ALS Clinical Trials: A New Era Ahead

2 months ago

ALS research is transforming rapidly! From isolated studies to global networks, trials now boost patient access, speed up data collection,…

Targeting Aging Pathways with GLP-1 Analogs: From Metabolic Disorders to Healthspan Extension

2 months ago

During the August convening of the Aging Research and Drug Discovery conference in Copenhagen, representatives from Novo Nordisk and Eli…

Assessment of Residual Plasmid DNA and SV40 Promoter-Enhancer Elements in modRNA-Based COVID-19 Vaccines from Pfizer-BioNTech and Moderna Sourced in Ontario, Canada

2 months ago

David J. Speicher and colleagues. Autoimmunity. 2025 Dec;58(1):2551517. doi: 10.1080/08916934.2025.2551517. Epub 2025 Sep 6. Abstract In the development of certain…

Advancements in Artificial Intelligence for Variant Pathogenicity Prediction in Genetic Disorders

2 months ago

The human genome harbors numerous subtle sequence variations, termed variants, which influence protein synthesis within cellular processes. Among these, only…

Advancements in Antimalarial Therapy: Phase III Outcomes for a Novel Ganaplacide-Lumefantrine Combination

2 months ago

Recent Phase III trial data from Novartis have demonstrated the efficacy of GanLum, an innovative antimalarial regimen comprising ganaplacide and…

Artificial Intelligence in Enhancing the Predictability of CRISPR-Based Genome Editing

2 months ago

Advancements in artificial intelligence (AI) are increasingly intersecting with genome editing technologies, potentially mitigating the inherent uncertainties associated with CRISPR…

A Novel Off-the-Shelf mRNA Vaccine Enters Human Trials for Cancer Treatment

2 months ago

A novel mRNA therapeutic vaccine targeting cancer has progressed to clinical evaluation in humans, offering the potential to broaden therapeutic…